Pulmonary function evolution
The mean changes in FEV1 were -7.0±22.6% for the first period
[Y-1-Y0], -2.1±16.8% for the second [Y0-Y+1] and +0.9±12.1%
for the last period [Y+1-Y+2]. The difference between FEV1 change
between the first and the last period was significatively significant,
with an improvement for [Y+1-Y+2] (p value <0.01).
No significant difference was observed between the periods [Y-1-Y0]
and [Y0-Y+1] for FEV1. There was a trend to a significant difference
between [Y0-Y+1] and [Y+1-Y+2], p=0.056, with higher FEV1 in the
period [Y+1-Y+2]. Data are summarized in Figure 1.