4.3 Strengths and weaknesses of this study
We performed a thorough reanalysis of clinical and research MBW data using the corrected algorithm incorporated in Spiroware 3.3.1, with data originally collected or reloaded in Spiroware 3.2.123. We performed rigorous quality control with only perfect data being used 15 which minimizes bias due to sampling variation. Further, we were able to use a wide range of different datasets obtained in a clinical routine setting or from clinical studies to assess the impact of measurement correction on various clinimetric properties of LCI. By nature, the main limitation lies in the retrospective application of the correction.