(a) discrimination between health and disease
ULN based on 75 healthy controls from a retrospective dataset1 was lower in Spiroware 3.3.1 with LCI 7.1 compared
to 8.1 in 3.2.1. Sensitivity was comparable (77.8% (3.2.1) and 76.2%
(3.3.1)) and specificity identical (98.7%) between 3.2.1 and 3.3.1 with
some scatter in the critical area (Figure 1, Supplemental Figure 2)
based on natural variability. In Spiroware 3.3.1, two children with CF
had abnormal LCI values compared to normal values in 3.2.1, while one
healthy child was falsely categorized as abnormal based on slightly
elevated LCI. In both Spiroware versions LCI values of all the other
healthy controls were within normal range and 15 children with CF had
values below the ULN.