b) correlation with functional MRI outcomes
We reanalyzed the correlation of functional MRI and LCI in 14 children with CF. The extent of QDP ranged between 15% and 35% (Figure 2) The correlation between QDP and LCI remained consistently strong in both Spiroware versions (3.2.1: rS=0.66, p=0.03; 3.3.1: rS=0.69 p=0.02). The increase in LCI per increase in ventilation defect was comparable for both Spiroware versions (Spiroware 3.2.1: 1.28 LCI units/percent perfusion defect (95% CI 0.67; 1.89); Spiroware 3.3.1: 1.32 LCI units/percent perfusion defect (95% CI 0.55; 2.10); Supplemental Figure 3).