Online Supporting Information
Appendix S1: PITCHES secondary analysis statistical analysis
plan (SAP).
Appendix S2: Minimal clinically important difference survey
questions.
Table S1: Maternal baseline characteristics and outcomes.
Table S2: Perinatal outcomes.
Table S3: Demographics of MCID survey respondents.
Figure S1: Flow diagram of participants.
Figure S2: Bile acid concentration stratified by initial bile
acid trajectory in women with baseline bile acid concentration
<40 µmol/L and ≥40 µmol/L.
Figure S3: Itch score stratified by initial bile acid
trajectory.
Figure S4: Results of survey question 1.
Figure S5: Results of survey question 1 by previous experience
of ICP.
Figure S6: Results of survey question 2.