Limits of the study
Nevertheless, we are aware that our study has limitations, as we designed a retrospective trial and included small numbers of patients. The possibility of designing a prospective study is also evaluated, and we plan to conduct a larger study to increase our sample size. However, the small sample size is due to our choice to include patients with high motivation for the treatment success. AIT works only if it is taken adequately by the patient, and when this occurs, we demonstrated that it works well. This evidence represents a crucial motivation for patients approaching the AIT because they take responsibility for their well-being. If the treatment is taken adequately and constantly, the patient will achieve several advantages, such as improvement of clinical symptoms, quality of life, and sparing of symptomatic therapy.