ASM; Airway smooth muscle, COPD; Chronic obstructive pulmonary disease, CS; Cigarette smoke, DM; Diabetes mellitus, DMSO; Dimethyl sulfoxide, ECM; Extracellular matrix, ECP; Eosinophil cationic protein, GLP-1;glucagon like peptide-1, HUVECs; Human umbilical vein endothelial cells, MAPK; Mitogen-activated protein kinase,MMP-9 ; Matrix metalloproteinase-9, MN;Monocytes, MPO; Myeloperoxidase, NE; Neutrophil elastase, NETs; Neutrophil extracellular traps, NF-κB;Nuclear factor-kappa B, OVA; Ovalbumin, PASMCs;Pulmonary artery smooth muscle cells, PMNs;Polymorphonuclear leukocytes, PLTs; Platelets, STAT3;Signal transducer and activator of transcription 3