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Fertility Assessment and Treatment in Adolescent and Young Adult (AYA) Cancer Survivors
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  • Molly Moravek,
  • Mary Ellen Pavone,
  • Karen Burns,
  • James Kashanian,
  • Richard Anderson,
  • James Klosky,
  • seth rotz,
  • Kate Stern,
  • Kenny Rodriguez-Wallberg,
  • Jennifer Levine,
  • Lillian Meacham
Molly Moravek
University of Michigan
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Mary Ellen Pavone
Northwestern University Feinberg School of Medicine
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Karen Burns
Cincinnati Children's Hospital Medical Center
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James Kashanian
Cornell University Joan and Sanford I Weill Medical College
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Richard Anderson
The University of Edinburgh MRC Centre for Reproductive Health
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James Klosky
Emory Healthcare
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seth rotz
Cleveland Clinic Foundation
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Kate Stern
Melbourne IVF
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Kenny Rodriguez-Wallberg
Karolinska Institute
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Jennifer Levine
Cornell University Joan and Sanford I Weill Medical College
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Lillian Meacham
Emory University School of Medicine
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Peer review status:IN REVISION

01 Jul 2020Assigned to Editor
01 Jul 2020Submission Checks Completed
01 Jul 2020Submitted to Pediatric Blood & Cancer
02 Jul 2020Reviewer(s) Assigned
09 Jul 2020Review(s) Completed, Editorial Evaluation Pending
03 Aug 2020Editorial Decision: Revise Major

Abstract

In the survivorship setting, adolescent and young adult (AYA) cancer survivors frequently demonstrate little knowledge of infertility risk, are unclear regarding their fertility status and may under- or over-estimate their treatment-related risk for infertility. In female AYA survivors, ovarian function usually parallels fertility, and can be assessed with serum hormone levels and ultrasonography. Post-treatment fertility preservation may be appropriate for survivors at risk for primary ovarian insufficiency. In male AYA survivors, fertility and gonadal function are not always equally affected, and can be assessed with a semen analysis and serum hormones, respectively. As reproductive health issues are commonly cited as an important concern by survivors of AYA cancer, multidisciplinary care teams including oncology, endocrinology, psychology, and reproductive medicine are advocated, with the aim of optimal provision of fertility advice and care for AYA cancer survivors.