Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), a new virus from Corona viruses family, was detected in China in December 2019. The virus was suddenly and vigorously disseminated among individuals allover the world hence the control on the virus was lost and COVID-19 pandemic was announced. Scientists start to screen all the available options to treat this newly evolved virus. Till now there is no validated treatment for SARS-CoV-2 patients and all drugs are under clinical investigation. This mini-review represents a summarized insight for the pathophysiology and the available SARS-CoV-2 therapy with the clinical trials associated with each drug category including antivirals, monoclonal antibodies, anticoagulants, convalescent plasma therapy, miscellaneous and adjuvant therapies.