3.5.1 Glucocorticoids and LPS-induced oxidative stress
Betamethasone and methylprednisolone-treated cells stimulated with LPS (40 pg/mL) showed a significant decrease of sNox2-dp compared to LPS-stimulated cells alone (Figure 5A). This effect was dose-dependent with a significance reached at concentrations of 300 and 600 ng/ml compared to 150 ng/ml (Figure 5A). Furthermore, both betamethasone and methylprednisolone-treated cells stimulated with LPS encompassed a significant decrease of H2O2 production compared to LPS-stimulated cells alone (Figure 5B). This effect was dose-dependent with a significance reached at concentrations of 300 and 600 ng/ml compared to 150 ng/ml (Figure 5B).