Results
A total of 106 cycles met the Bologna criteria (44.8%) in this study period. Among these cycles, they were divided into group A with supplementation of DHEA combining Metformin (n = 64) and group B without supplementation (n = 42). There were no differences between the two groups regarding age, body mass index, basal follicle stimulation hormone concentration (FSH), basal estradiol concentration (E2), basal antral follicle counts (AFC), Anti-Müllerian hormone concentration (AMH) and Bologna criteria category.
The treatment cycle outcomes between the two groups were compared (Table 1). There were no significant differences in terms of stimulation duration, gonadotropin dosage, estradiol level on hCG day, and fertilization rate. Although not statistically significant, there is a trend of higher number of metaphase II oocytes retrieved (2.1±1.5 vs. 1.0±0.8, p = 0.115) in group A than group B. Furthermore, the number of oocytes retrieved (3.5±2.5 vs. 1.5±0.8, p = 0.027), the clinical pregnancy rate (21.7 vs. 11.5, p = 0.008) and the live birth rates (16.7 vs. 8.7, p = 0.007) were significantly higher in group A than in group B.