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Dehydroepiandrosterone(DHEA) combining Metformin – Adjuvant Agents for Ovulation Induction in Poor Ovarian Responders
  • Chih-Chia Chang,
  • Yu Chang,
  • YU Chang
Chih-Chia Chang
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Yu Chang
Chang Hua Christian Hospital
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YU Chang
National Taiwan University Hospital
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Abstract

Objective: To investigate the impact of Dehydroepiandrosterone(DHEA) combining Metformin on IVF-ET outcomes in poor ovarian responders(PORs). Materials and Methods: This is a retrospective cohort study. There were 237 women undergoing IVF-ET cycles. A total of 106 cycles met the Bologna criteria (44.8%) as poor responders in this study period. They were divided into two groups according to with or without supplementation. Results: The number of oocytes retrieved (3.5±2.5 vs. 1.5±0.8, p = 0.027), the clinical pregnancy rate(21.7 vs. 11.5, p = 0.008) and the live birth rate(16.7 vs. 8.7, p = 0.007) were significantly higher in the group with supplementation than in the group without. Conclusion: The adjuvant agents: DHEA and Metformin for ovulation induction seemed to improve the number of oocytes retrieved, clinical pregnancy rate and live birth rates in poor ovarian responders.