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Overlapping tumor-specific expression of p53, p16INK4a , and sirtuin 1 in Bowen’s Disease: A Case Report
  • Tomoaki TakadaOrcid
Tomoaki Takada
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Peer review status:UNDER REVIEW

29 Jun 2020Submitted to Clinical Case Reports
01 Jul 2020Assigned to Editor
01 Jul 2020Submission Checks Completed
19 Jul 2020Reviewer(s) Assigned


The tumor of a patient with Bowen’s disease exhibited expression of the tumor suppressors p53 and p16INK4a(p16), which correlated with cytoplasmic expression of the histone deacetylase sirtuin 1(SIRT1). Epigenetic regulation of p53 and p16 by SIRT1 may play a role in the carcinogenesis of Bowen’s disease.