Case report:
A female of 28 years with history of left leg bullock cart injury admitted in emergency, having fever and multiple skeleton muscle spasms, specially lockjaw and opisthotonos. She was kept in tetanus ward and managed conservatively in dark room for 24 hrs with high dose sedatives (Diazepam), antibiotics and antipyretic measures with debridement and dressing of wound done, ATS was also given. Then waited for 24 hours until now she continuously presented with lockjaw and multiple respiratory muscle spasm.
Then we put Ryle’s tube and dopamine agonists in the form of Levodopa and carbidopa combination (Syndopa 275 mg) given. The muscle spasm, a characteristic feature of tetanus, is much relived. The patient got relief not only in exhaustion but also regained smooth respiration. This treatment continued for 2 to 3 weeks till normal knee and ankle jerks and stabilization of patient.
After 3 weeks patient was discharged with no residual tetanic spasm and then Syndopa was stopped.
Since this is the pilot study in a single case with excellent result, we are planning to study with more cases.