Study population
We evaluated 314 patients in our study period, of which 236 had
completed clinical and echocardiographic evaluation for our main
analyses (Supplementary Figure 1 ). Characteristics and
echocardiographic assessment of our first cohort sample are presented inTable 1 . Briefly, our population had a male predominance
(52.9%), with a mean age of 55 (±15) years. The echocardiographic
evaluation showed a median peak RV-longitudinal FWS of -26.9% (IQR:
-31.2% to -21.2%) and a peak RA-GLS of 42.2% (IQR: 30.6% to 55.0%).
Median systolic pulmonary arterial pressure was 33 (IQR: 28-41) mmHg. In
our studied sample, 134 (56.8%) had normal sPAP values, from peak TR
velocity, which represented our control group; 102 (43.2%) were
classified with probability of pulmonary hypertension. Of these
patients, 58 (56.9%) had low, 15 (14.7%) intermediate, and 29 (28.4%)
high probability of pulmonary hypertension. Finally, in the 13 patients
submitted to cardiac catheterization, we observed an acceptable
inter-rater reliability coefficient (IRC: 56.8%) with echocardiographic
sPAP parameters and an overall variance with the mean between both
parameters ≤30% (Supplementary Figure 2 ).