Sensitivity analysis
Sensitivity analysis for the secondary endpoints involving the removal
of each of the studies sequentially demonstrated that if some of the
studies were removed from the analysis, the summary risk estimates for
the composite survival-free VT/VF and appropriate ICD therapies was not
influenced making the overall results significant (Figure 4 ).
The chronologic cumulative analysis for each outcome before inclusion of
all studies in the final effect summary did not have a significant
impact in the overall final effect (oldest RCT from 2007 and most recent
in 2020) (Figure 4 ).