Secondary endpoints
In patients with moderately depressed LVEF (>30-50%), survival-free from VT/VF in patients who underwent first-line catheter ablation was 56% vs. 45% in those receiving conservative treatment. A significant benefit of survival-free from VT/VF was observed with first-line catheter ablation, with a 24% relative risk reduction and 11% absolute risk reduction when compared with the medical treatment group (HR: 0.56, 95% CI: 0.38-0.83) (Figure 2 ).
First line VT ablation was associated with a statistically significant reduction in the composite endpoint of survival-free VT/VF and appropriate ICD therapies in patients with moderately reduced LVEF (HR: 0.52, 95% CI: 0.36-0.76) (Figure 3) . In patients with severely depressed LVEF (</=30%), first line VT ablation was not associated with a reduction in the composite endpoint of survival-free VT/VF and appropriate ICD therapies (HR: 0.56, 95% CI: 0.24-1.32)(Figure 3) .