Rhabdomyosarcoma of the uterus
RMS of the uterus can be found at the cervix uteri or the corpus uteri.
The pooled analysis of 237 international patients showed a median age at
diagnosis of 2.9 years for uterine primary compared to 13.5 years for
cervical primaries.4 Additionally, tumors were less
frequently located at the cervix (21%) or the uterus (11%) compared to
the vagina (68%). Most of the tumors have FOXO1 fusion negative
embryonal histology.4 Analysis of the IRS-I to -IV
trials revealed a higher incidence for stage IV disease in patients with
RMS of the uterus.6 Patients with tumors located at
the uterus have the worst overall survival in comparison to those
located at the cervix or vagina.4 Local therapy
differs between tumor located at the cervix uteri or the corpus uteri.
Therefore, local control is described separately.