Rhabdomyosarcoma of the uterus
RMS of the uterus can be found at the cervix uteri or the corpus uteri. The pooled analysis of 237 international patients showed a median age at diagnosis of 2.9 years for uterine primary compared to 13.5 years for cervical primaries.4 Additionally, tumors were less frequently located at the cervix (21%) or the uterus (11%) compared to the vagina (68%). Most of the tumors have FOXO1 fusion negative embryonal histology.4 Analysis of the IRS-I to -IV trials revealed a higher incidence for stage IV disease in patients with RMS of the uterus.6 Patients with tumors located at the uterus have the worst overall survival in comparison to those located at the cervix or vagina.4 Local therapy differs between tumor located at the cervix uteri or the corpus uteri. Therefore, local control is described separately.