Patient Sex Age Diagnosis Status Blast% before CART MRD before CART Chemotherapy CART type Donor type CART (*10^6/kg) CRS MRD (%) after CAR-T MRD (%) after CAR-T Re-BMT after CART
1 M 17y R/R B-ALL Relapse after transplantation 6% 4.65% Flu+CTX DD MSD 12.6 Grade 2 CR CR No
2 M 5y R/R B-ALL Relapse after transplantation 8% 1.02% Flu+CTX DD HRD 13.3 Grade 1 CR CR No
Author / publication time
Author / publication time
Cases
status before CAR-T treatment
status before CAR-T treatment
status before CAR-T treatment
Type of transplantation
Type of transplantation
CART type
Transfusion cell count
Transfusion cell count
CRS (case)
CRS (case)
GVHD (case)
Clinical outcome
Cruz et al(2013)[12] Cruz et al(2013)[12] 4 2 cases relapsed, 2 cases MRD (+) 2 cases relapsed, 2 cases MRD (+) 2 cases relapsed, 2 cases MRD (+) MUD/MSD MUD/MSD DD 3.15×107~1.13×108 3.15×107~1.13×108 0 0 0 3 cases remission, 1 case progressed
Brudno et al(2016)[13] Brudno et al(2016)[13] 6 2 cases recurred and 3 cases progressed 2 cases recurred and 3 cases progressed 2 cases recurred and 3 cases progressed MUD/MSD MUD/MSD DD 5×106~10×106 5×106~10×106 5 0 0 4 cases remission and 1 case progressed
Kebriaei et al(2016)[7] Kebriaei et al(2016)[7] 9 Preventive reinfusion within 6~12 weeks after transplantation Preventive reinfusion within 6~12 weeks after transplantation Preventive reinfusion within 6~12 weeks after transplantation HRD HRD DD 1×106~5×108 1×106~5×108 0 2 2 5 cases long-term survival
Kebriaei et al(2016)[7] Kebriaei et al(2016)[7] 8 Preventive reinfusion within 6~12 weeks after transplantation Preventive reinfusion within 6~12 weeks after transplantation Preventive reinfusion within 6~12 weeks after transplantation MSD MSD DD 1×106~5×108 1×106~5×108 0 1 1 5 cases long-term survival
chen et al(2017)[8] chen et al(2017)[8] 6 Hematological recurrence Hematological recurrence Hematological recurrence HRD HRD DD 6.3×107~2.6×108 6.3×107~2.6×108 5 3 3 5 cases CR and relapsed after 2~7 months.
Cheng et al(2019)[9] Cheng et al(2019)[9] 6 MRD(+) MRD(+) MRD(+) HRD HRD DD 2×107~3.66×108 2×107~3.66×108 5 0 0 5 cases CR and 3 cases long-term survival