1 |
M |
17y |
R/R B-ALL |
Relapse after transplantation |
6% |
4.65% |
Flu+CTX |
DD |
MSD |
12.6 |
Grade 2 |
CR |
CR |
No |
2 |
M |
5y |
R/R B-ALL |
Relapse after transplantation |
8% |
1.02% |
Flu+CTX |
DD |
HRD |
13.3 |
Grade 1 |
CR |
CR |
No |
Author / publication time
|
Author / publication time
|
Cases
|
status before CAR-T treatment
|
status before CAR-T treatment
|
status before CAR-T treatment
|
Type of transplantation
|
Type of transplantation
|
CART type
|
Transfusion cell count
|
Transfusion cell count
|
CRS (case)
|
CRS (case)
|
GVHD
(case)
|
Clinical outcome
|
Cruz et al(2013)[12]
|
Cruz et
al(2013)[12]
|
4 |
2 cases relapsed, 2 cases MRD
(+) |
2 cases relapsed, 2 cases MRD (+) |
2 cases relapsed, 2 cases MRD
(+) |
MUD/MSD |
MUD/MSD |
DD |
3.15×107~1.13×108
|
3.15×107~1.13×108
|
0 |
0 |
0 |
3 cases remission, 1 case progressed |
Brudno et al(2016)[13]
|
Brudno et
al(2016)[13]
|
6 |
2 cases recurred and 3 cases
progressed |
2 cases recurred and 3 cases progressed |
2 cases recurred
and 3 cases progressed |
MUD/MSD |
MUD/MSD |
DD |
5×106~10×106
|
5×106~10×106
|
5 |
0 |
0 |
4 cases remission and 1 case progressed |
Kebriaei et al(2016)[7]
|
Kebriaei et
al(2016)[7]
|
9 |
Preventive reinfusion within
6~12 weeks after transplantation |
Preventive reinfusion
within 6~12 weeks after transplantation |
Preventive
reinfusion within 6~12 weeks after transplantation |
HRD |
HRD |
DD |
1×106~5×108
|
1×106~5×108
|
0 |
2 |
2 |
5 cases long-term survival |
Kebriaei et al(2016)[7]
|
Kebriaei et
al(2016)[7]
|
8 |
Preventive reinfusion within
6~12 weeks after transplantation |
Preventive reinfusion
within 6~12 weeks after transplantation |
Preventive
reinfusion within 6~12 weeks after transplantation |
MSD |
MSD |
DD |
1×106~5×108
|
1×106~5×108
|
0 |
1 |
1 |
5 cases long-term survival |
chen et al(2017)[8]
|
chen et
al(2017)[8]
|
6 |
Hematological recurrence |
Hematological recurrence |
Hematological recurrence |
HRD |
HRD |
DD |
6.3×107~2.6×108
|
6.3×107~2.6×108
|
5 |
3 |
3 |
5 cases CR and relapsed after 2~7
months. |
Cheng et al(2019)[9]
|
Cheng et
al(2019)[9]
|
6 |
MRD(+) |
MRD(+) |
MRD(+) |
HRD |
HRD |
DD |
2×107~3.66×108
|
2×107~3.66×108
|
5 |
0 |
0 |
5 cases CR and 3 cases long-term survival |