Methods:
Verified physiologicallyâbased pharmacokinetic (PBPK) models were used
study the effect of COVID-19 drugs PK in geriatric patients, race, organ
impairment, DDI risks, disease-drug interaction for repurposed COVID-19
drugs. Furthermore, these models were used to predict epithelial lining
fluid (ELF) exposure which is relevant for COVID-19 patients by
accounting for the interplay between cytokines and metabolic
disposition.