What is already known
about this subject?
- Disease-drug interactions can result in exposure changes, which are
well documented in cancer, cirrhosis, and rheumatoid arthritis.
Cytokine storms are known to perturb the expression of CYP enzymes,
conjugative enzymes, and transporters.
- Clinically observed pharmacokinetic data and the effect of race on
repurposed COVID-19 drugs in geriatric COVID-19 patients are limited.
- There is some knowledge of the effect of intrinsic and extrinsic
factors on the disposition of repurposed COVD-19 drugs, but dosing
recommendations during cytokine storm are lacking