Clinical evidence linking allergy to risk of CRS in children Clinical evidence linking allergy to risk of CRS in children Clinical evidence linking allergy to risk of CRS in children Clinical evidence linking allergy to risk of CRS in children Clinical evidence linking allergy to risk of CRS in children Clinical evidence linking allergy to risk of CRS in children
Author Year ( ) ref
Type of article
No. of cases (mean age)
Methods
Relevant results
Association (Level of evidence)
Sedaghat et al. 2014 (57)
Retrospective analysis.
N= 4044 children with CRS (8.9 yr).
Retrospective review of children diagnosed as uncomplicated CRS by an otolaryngology or allergy office evaluation
Comorbidities observed in CRS children were primary ciliary dyskinesia (0.2%), cystic fibrosis (4.1%), immunologic disorder (12.3%) and AR (26.9%).
Inconclusive (Level IV)
Choi et al. 2012 (34)
Prospective study.
N=296 (<13yr) with RS
To evaluate predisposing factors for chronic and recurrent rhinosinusitis (RS).
The prevalence of AR, atopy, and asthma were significantly higher in patients with CRS and recurrent RS than those with acute and subacute RS.
Yes (Level II)
Anamika et al. 2019 (58)
Cross-sectional study.
N=110 children with CRS (7-18yr).
To determine atopic profile of children with CRS and impact of atopic status on disease severity and quality of life.
Positive skin prick test was present in 52.7% of patients. Atopic CRS had a significant higher mean Lund-Mackay endoscopic score and symptoms scores than non-atopic ones.
Yes (Level IV)
Huang 2000 (59)
Prospective observational study
N= 413 RA children. (3-15 yr). To evaluate mold allergy as risk factor for sinusitis. The authors compared 215 PAR to 198 SAR.
The prevalence of sinusitis was significantly higher among patients with PAR than among those with SAR regardless of age or season; patients with mold allergy PAR had a higher risk than those with non-mold allergy.
Yes (Level II)
Leo et al. 2007 (60)
Cross-sectional study
N=351 children with CRS (5.23 ± 2.11 yr)
CRS underwent allergen sensitization work-up by skin prick test with common inhalant allergens and total IgE measurement.
Prevalence of sensitization to aeroallergens in children with CRS is comparable with that of the general pediatric population.
No (Level IV)
Clinical evidence linking allergy to outcome of CRS treatments in children Clinical evidence linking allergy to outcome of CRS treatments in children Clinical evidence linking allergy to outcome of CRS treatments in children Clinical evidence linking allergy to outcome of CRS treatments in children Clinical evidence linking allergy to outcome of CRS treatments in children Clinical evidence linking allergy to outcome of CRS treatments in children
Nathan et al. 2004 (64)
Prospective observational study
N= 114 RA and CRS (children and adult)
Patients were surveyed for global symptoms and specific symptoms related to the nose, sinuses, eyes, and chest with the SOQ
Immunotherapy is an effective treatment for patients with sinus disease and allergic rhinitis.
Yes (Level II)
Ramadan, & Hinerman 2006 (63)
Prospective observational study.
N= 141 patients who underwent ESS (7 yr)
To evaluate outcome of ESS at 1 year after the operation.
Children with AR who were on treatment before surgery had an 84% success rate compared with 62% for those children with non-treated AR by immunotherapy.
Yes (Level II)
Kim et al. 2005 (65)
Retrospective observational study.
N=97 patients (age range: 5—15 years)
Retrospective analysis of long-term success rates of ESS respect to several predisposing factors.
Multivariate logistic regression analysis allergy was not correlated to poor outcomes after pediatric ESS
No (Level IV)
El Sharkawy 2012 (66)
Prospective observational study.
N=87 children (45 with nasal allergy) (age≤14)
To assess predictive factors of outcome after ESS.
The success rate in CRS with nasal allergy was 87.5%, and in CRS without nasal allergy was 85.7%.
No (Level II)
Lee et al. 2009 (68)
Retrospective analysis
N=53 children who underwent FESS (age<18yr)
To investigate factors leading to protracted nasal discharge after pediatric endoscopic sinus surgery.
Blood eosinophil count did not differ significantly between the “protracted” and the “resolved” groups. On the other hand, history of allergic rhinitis was more frequently observed in the “protracted” group.
Yes (Level IV)
Wu et al. 2019 (69)
Retrospective analysis
N=188 children ESS for CRS.
To evaluate prognostic factors related to revision surgery after ESS.
Patients with positive aeroallergen tests had higher rates of CRS recurrence after ESS and required revision surgery.
Yes (Level IV)