Search strategy
This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process to identify published experimental and clinical articles about allergy and rhinosinusitis including common cold in children. Manuscript were screened primarily by Ovid Medline and EMBASE and from other sources (Pubmed Central, Cochrane review, Web of Science, and Google Scholar) and published from January 2000 to April 2020. Only 3 articles before this date were included because considered particularly relevant for this systematic review. Literature searches were performed in April 2020.
We performed two different searches using MeSH-terms. One group of authors focused on experimental studies matching the term as follow: ((Rhinovirus) OR (coronavirus) OR (epithelial barrier) OR (epithelial cells) OR (barrier function) OR (nasal epithelial cells) OR (viral infections)) AND ((Allergy) OR (Allergic rhinitis) OR (Atopy) OR (Atopic) OR (Allergic Children) OR (Non allergic children) OR (immunoglobulin E)) AND ((children) OR (childhood) OR (pediatric)). The second group of authors focused on clinical studies, matching the term as follow: ((respiratory infections) OR (acute rhinosinusitis) OR (Chronic rhinosinusitis) OR (Sinusitis) OR (Rhinosinusitis) OR (Recurrent sinusitis) OR (endoscopic sinus surgery) OR (URTI) OR (Upper Recurrent Respiratory Infection)) AND ((Allergy) OR (Allergic rhinitis) OR (Atopy) OR (Atopic) OR (Allergic Children) OR (Non allergic children) OR (immunoglobulin E) OR (immunotherapy) OR (antihistamine)) AND ((children) OR (childhood) OR (pediatric)).