Search strategy
This systematic review was conducted in accordance with the Preferred
Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process
to identify published experimental and clinical articles about allergy
and rhinosinusitis including common cold in children. Manuscript were
screened primarily by Ovid Medline and EMBASE and from other sources
(Pubmed Central, Cochrane review, Web of Science, and Google Scholar)
and published from January 2000 to April 2020. Only 3 articles before
this date were included because considered particularly relevant for
this systematic review. Literature searches were performed in April
2020.
We performed two different searches using MeSH-terms. One group of
authors focused on experimental studies matching the term as
follow: ((Rhinovirus) OR (coronavirus) OR (epithelial barrier) OR
(epithelial cells) OR (barrier function) OR (nasal epithelial cells) OR
(viral infections)) AND ((Allergy) OR (Allergic rhinitis) OR (Atopy) OR
(Atopic) OR (Allergic Children) OR (Non allergic children) OR
(immunoglobulin E)) AND ((children) OR (childhood) OR (pediatric)). The
second group of authors focused on clinical studies, matching the
term as follow: ((respiratory infections) OR (acute rhinosinusitis) OR
(Chronic rhinosinusitis) OR (Sinusitis) OR (Rhinosinusitis) OR
(Recurrent sinusitis) OR (endoscopic sinus surgery) OR (URTI) OR (Upper
Recurrent Respiratory Infection)) AND ((Allergy) OR (Allergic rhinitis)
OR (Atopy) OR (Atopic) OR (Allergic Children) OR (Non allergic children)
OR (immunoglobulin E) OR (immunotherapy) OR (antihistamine)) AND
((children) OR (childhood) OR (pediatric)).