Figure legend
Figure 1. Replicative capacity of variant viruses with indicated
PA/I38 substitutions in MDCK cells. MDCK cells were infected with
wild-type (WT) or indicated mutant viruses based on rgA/WSN/33(H1N1) (A,
C) and rgA/Victoria/3/75(H3N2) (B, D). The culture supernatants were
collected at the indicated time points and viral titers
(TCID50/mL) were determined in MDCK cells. Each plot
represents the mean and standard deviation of triplicate experiments.
The lower limit of quantification of the virus titers was indicated by a
dashed line. *P < 0.05 to WT by Welch’s t -test
at the indicated time point.