ACKNOWLEDGEMENTS
Robert Webster (St. Jude Children’s Research Hospital, Memphis) kindly provided materials for reverse genetics. We appreciate acknowledge Takeki Uehara, Kenji Tsuchiya, Keiko Kawaguchi, Toru Ishibashi and Naohisa Kitade (Shionogi & Co. Ltd.) for analyzing and providing clinical data. We acknowledge Satoshi Kojima and Masahiro Kinoshita for assistance in manuscript preparation. We thank Makoto Iwasaki, Michie Watanabe, Saya Nishimori-Yamaki, and all members of Shionogi TechnoAdvance Research, Co., Ltd. for excellent technical assistance. The work on this project was supported with research funds provided by Shionogi & Co., Ltd. Osaka, Japan and F. Hoffmann-La Roche Ltd, Basel, Switzerland.