Figure 2 - Genetic, environmental and behavioral factors contribute, together with comorbidities, to determine the degree of upper airway Type-2 inflammation, with consequences on clinical expression and severity (i.e.: recurrence after surgical treatment) of chronic rhinosinusitis. A: Post-nasal drip, as an example of pure upper airway inflammatory involvement; B: Chronic rhinosinusitis with nasal polyps, a more structured inflammatory condition; C: CT-scan with extendend chonic rhinosinusitis with concomitant bone remodeling as consequence of chronic inflammation.