A greater heparin requirement with edoxaban
We also showed that the greatest heparin requirement was seen in the
edoxaban group. To date, little is known about an interaction between
unfractionated heparin and edoxaban. However, we recently demonstrated
in a study [22] that there was an inverse correlation between the
residual DOAC activity and heparin requirement during AF ablation, and
among the 4 DOACs, it was the weakest for edoxaban. That may seemingly
be in line with the finding, and possibly suggest edoxaban’s weaker
interaction with heparin.