Endpoints
The primary endpoints were intraablation anticoagulation parameters including the ACT, time from the initial heparin injection to the first achievement of the target ACT, and heparin requirement. The secondary endpoint was a fall in the hemoglobin level 24 hours after the ablation. The occurrence of major or minor bleeding complications was also measured. Major bleeding complications were defined as the occurrence of a cardiac tamponade, hematoma requiring intervention, hemothorax, or retroperitoneal bleeding. Minor bleeding complications were defined as a hematoma or any bleeding that did not require any intervention or a prolonged hospital stay [18].