A greater heparin requirement with edoxaban
We also showed that the greatest heparin requirement was seen in the edoxaban group. To date, little is known about an interaction between unfractionated heparin and edoxaban. However, we recently demonstrated in a study [22] that there was an inverse correlation between the residual DOAC activity and heparin requirement during AF ablation, and among the 4 DOACs, it was the weakest for edoxaban. That may seemingly be in line with the finding, and possibly suggest edoxaban’s weaker interaction with heparin.