Binswanger’s disease is a complex neuro-psychiatric disease and its
pathophysiology is only partially understood. As new pathophysiological
mechanisms are revealed, other tests will become available in the years
to come and also novel therapies will specifically target these
mechanisms (inflammation, arterial stiffness and clearance of cerebral
waste) in order to better treat these patients.
The particularity of our case resides in the fact that the white matter
lesions were diffuse, extending from infratentorial to the brainstem,
cerebellar peduncles and the cerebellum, which is not common in
Binswanger’s disease and is rarely described in literature.