Conclusions

Binswanger’s disease is a complex neuro-psychiatric disease and its pathophysiology is only partially understood. As new pathophysiological mechanisms are revealed, other tests will become available in the years to come and also novel therapies will specifically target these mechanisms (inflammation, arterial stiffness and clearance of cerebral waste) in order to better treat these patients. The particularity of our case resides in the fact that the white matter lesions were diffuse, extending from infratentorial to the brainstem, cerebellar peduncles and the cerebellum, which is not common in Binswanger’s disease and is rarely described in literature.