Age, years |
61 (50-68) |
61 (52-71) |
0.95 |
Male gender, n (%) |
39 (54.2) |
102 (55.1) |
0.89 |
BMI, kg/m2
|
29.7 (26.9-33.0) |
30.8 (26.3-33.9) |
0.57 |
Time from disease onset to enrollment, days |
10 (7-12) |
8 (6-10) |
<0.01 |
Persistent fever, n (%) |
60 (83.3) |
133 (71.9) |
0.08 |
CRP>50 mg/L, n (%) |
60 (83.3) |
182 (98.4) |
<0.01 |
Comorbidities, n (%) |
|
|
|
Hypertension |
41 (56.9) |
111 (60.0) |
0.67 |
Diabetes |
13 (18.1) |
40 (21.6) |
0.61 |
Obesity |
29/61 (47.5) |
77/150 (51.3) |
0.65 |
History of stroke |
2 (2.8) |
11 (5.9) |
0.53 |
History of myocardial infarction |
3 (4.2) |
16 (8.6) |
0.29 |
Malignancy |
2 (2.8) |
7 (3.8) |
1.00 |
COPD |
2 (2.8) |
7 (3.8) |
1.00 |
Other* |
34 (47.2) |
91 (49.2) |
0.78 |
Oxygen support at enrollment, n (%) |
|
|
|
Nasal oxygen |
71 (98.6) |
184 (99.5) |
0.48 |
Non-invasive ventilation |
1 (1.4) |
1 (0.5) |
0.48 |
Oxygen saturation, % |
90 (87-92) |
90 (88-92) |
0.93 |
Extent of lung involvement on CT, n (%) |
|
|
|
0-24% |
2 (2.8) |
3 (1.6) |
0.62 |
25-49% |
37 (51.4) |
55 (29.7) |
<0.01 |
50-74% |
26 (36.1) |
105 (56.7) |
<0.01 |
≥75 |
7 (9.7) |
17 (9.2) |
1.00 |
Missing data |
|
|
|
Body temperature (axillary), °C |
38.0 (38.5-38.7) |
37.6 (37.2-38.1) |
<0.01 |
Blood parameters |
|
|
|
White cells, ×109/L |
5.9 (4.2-7.5) |
6.1 (4.8-8.1) |
0.70 |
Neutrophils, ×109/L |
4.1 (2.9-5.6) |
4.6 (3.4-6.3) |
0.19 |
Lymphocytes, ×109/L |
1.0 (0.7-1.3) |
0.9 (0.7-1.3) |
0.45 |
CRP, mg/L |
89.4 (62.6-154.2) |
106.5 (79.0-148.5) |
0.02 |
LDH, U/L |
654.5 (532.5-871.3) |
732.0 (566.5-894.0) |
0.46 |
Creatinine, mcmol/L |
93.4 (87.0-115.0) |
95.5 (84.7-115.9) |
0.81 |
Concomitant therapy, n (%) |
|
|
|
Antimalarials |
63 (87.5) |
173 (93.5) |
0.13 |
Lopinavir-ritonavir |
10 (13.9) |
80 (43.2) |
<0.01 |
Glucocorticoids |
31 (43.7) |
39 (21.1) |
<0.01 |
Azithromycin |
54 (75.0) |
157 (84.9) |
0.07 |
Other antibiotics |
47 (65.3) |
145 (78.4) |
0.04 |
Low molecular weight heparins |
69 (95.8) |
160 (86.5) |
0.04 |