2. Inhibitors of Epithelium Cell Entry
It has been widely reported that angiotensin-converting enzyme 2 (ACE2)
is likely to be the predominant cell surface receptor by which
SARS-CoV-2 is able to enter host cells (Hoffmann et al., 2020). ACE2 is
widely distributed in the body, but is particularly highly expressed on
lung alveolar cells, which could explain the increased lung damage seen
in some COVID-19 patients (Favalli et al., 2020; Zhao et al., 2020).