Title: Incidence and risk factors for preeclampsia in a cohort of high-risk pregnant women: a nested case-control study from South India
Objective : To explore the incidence and risk factors of preeclampsia (PE) among high- risk pregnant women in South India.
Design : Nested case- control study
Setting: Tertiary referral hospital
Population or Sample : Pregnant women with risk for PE.
Methods : Maternal characteristics were prospectively collected, and risk factors were assessed comparatively between women with risk for developing PE and normotensive pregnant women using risk ratio (RR) (95% CI) plus multivariate analysis. One hundred and seventy-four risk group pregnant women were followed-up once in each trimester till delivery and noted for the development of PE.
Main Outcome Measures : Incidence and risk factors of PE among high-risk pregnant women.
Results: 67/174 women developed PE, corresponding to an incidence of 38.51% among pregnant women with risk for PE. Women in the age group of 30 and older reported a higher incidence. Maternal factors like absence of family history of chronic hypertension, history of abortion, non-consanguineous marriage, and AB blood group were significant protective factor and sex of the new-born being female was a significant risk factor for developing PE.
Conclusion : This is the first Indian study that explored the incidence and risk factors for PE among high-risk pregnant women. Incidence of PE was higher among South Indian risk population. Female infants significantly contributed to the PE risk.
Funding: JIPMER Intramural Research fund.
Keywords: Preeclampsia; Incidence; South India; High-risk women; Follow-up; Risk factors
Tweetable Abstract: The incidence of PE is 38.51% and the significant risk factor is female foetus among high-risk pregnant women.