Location Histology Skin lesion
Capillary endothelium dermis Damage of vessels, endothelial swelling, perivascular edema, hemorrhage Macules, papules, petechiae
Dermis Edema, cellular infiltrate, hemorrhage, visualization of organism by electron microscopy Papules, urticaria, purpura, vesicles
Epidermis Cytopathic effects of the virus, i.e., inclusion, ballooning, vacuolar degeneration, necrosis Papules, vesicles, ulcer