3.3 Severe cutaneous adverse drug reaction
There are COVID-19 positive cases with DRESS (drug reaction with
eosinophilia and systemic symptoms) described (unpublished reports),
which is a severe cutaneous drug reaction with non-specific histologic
findings (Figure 9A and B). The diagnosis is based on a combination of
clinical symptoms and laboratory parameters including frequently
occurring hepatic abnormalities, eosinophilia and exanthema with facial
swelling and lymphadenopathy (73 ). The culprit drug should be
stopped immediately upon identification. In some cases, eosinophilia
could hardly be controlled with corticosteroids, which led to the
successful use of agents interfering with the IL-5 axis (unpublished
reports).