3.1 Drug induced urticarial rashes
Urticaria and urticarial rashes belong at least in part to cutaneous
type I (IgE-mediated) drug- hypersensitivity reactions (Table 3)(Fig.
7). Other mechanisms involved are direct mast cell activation, immune
complex formation/precipitation (Fig. 7) and activation of complement
during serum sickness or interaction with metabolic pathways of drugs
such as arachidonic acid metabolism (69 ). Urticaria or
urticarial rashes in SARS-CoV-2 patients could be drug induced, induced
by drugs, viral RNA or a mixture of both. Infection-associated
re-activation or exacerbation of pre-existing urticaria might be
possible as well.