Conclusion
Recent observation of involvement of the skin and the vasculature in subgroups of SARS-CoV-2 infected patients illustrates the need for a precise stratification and differential diagnostic evaluation of those patients in order to gain more insight into mechanisms of this novel virus. So far, pathophysiologic mechanisms behind the skin lesions occurring in the context of COVID-19 are speculative, could be related to the virus, drugs and other co-factors. Knowledge from other viral infections and drug induced lesions of the skin and vascular system might be transferred and observations on SARS-CoV-2 patients systematically evaluated to rapidly increase our knowledge on this issue. For mild cases of COVID-19, skin lesions can be a diagnostic hint; for severe cases, due to multiorganic involvement and interdisciplinary approach is of outmost importance.