I Specific IgE Anaphylaxis
II IgG or IgM Hemolytic anemia
III IgG or IgM Serum sickness
Type IVa Th1 (IFN-γ) Monocyte activation Eczema
Type IVb Th2 (IL-4/IL-5) Eosinophilic inflammation Maculopapular exanthema, Drug Rush with Eosinophilia and systemic symptoms (DRESS)
Type IVc
CTL Perforin/ Granzyme B
CD4/CD8 mediated killing of cells
Maculopapular exanthema Toxic epidermal necrolysis
Type IVd T cells (IL-8) Neutrophil activation Acute generalized exanthematic pustulosis (AGEP)
Type IVe Th2 cells CD4/CD8 cell activation