Figure 2l.

Results

Results of individual parameter fitting

In order to demonstrate the capabilities of the models, we first fitted them to complete individual time series data of the 135 patients of the primary data set. Resulting distributions of individual parameter settings are presented in Supporting information S.4, Supporting Tables S.4.1 for the mechanistic model. Both models showed good agreements with data in cases where the platelet nadirs of cycles are continuously declining during the course of therapy as shown in Figure 3. Of note, the semi-mechanistic model fits the first cycle better, while the mechanistic model fits the later cycles better. In cases of irregular dynamics without clear nadir trends, both models show stronger deviations from the data of up to 1-2 grades of thrombocytopenia as shown in Figure 4. For most patients with such irregular behavior, the mechanistic model outperforms the semi-mechanistic model (patients 14, 15, 398 and 1017). Irregular time courses are frequent especially for 14-day schedules which are supported by G-CSF administrations.