Types of studies
Only randomized controlled trials (RCTs) that have compared the four
different NRS treatments (HFNC, CPAP, BiPAP and NIPPV) were included.
Studies published as peer reviewed abstract form as well as non-english
language studies were included in the final synthesis. Neonates with
gestational age < 37 weeks with a primary diagnosis of RDS and
who were started on a NIV support within the first 24 hours of life.
Neonates who had received surfactant via standard practice (INSURE or
LISA) prior to randomisation were included.