Methods
A retrospective cohort study was conducted in general medical and
geriatric specialties at an Australian hospital, over six months.
Medication harm was identified using International Classification of
Disease (ICD-10) codes and the hospital’s incident database. Sixty-eight
variables, including medications and laboratory results, were extracted
from the hospital’s databases. Multivariable logistic regression was
used to develop the final risk model. Performance was evaluated using
area under the receiver operative characteristic curve (AuROC) and
clinical utility was determined using decision curve analysis.