Calculation of SYNTAX Scores
All baseline SYNTAX scores were calculated by an experienced interventional cardiologist who was blinded as to the treatment modality that was to be assigned to any particular patient. Baseline SYNTAX scores were derived from the initial coronary angiogram, prior to any intervention.
For those patients who underwent coronary artery bypass grafting (standard or hybrid coronary revascularization) the SYNTAX scores were calculated based on Farooq V et al’s methodology for the calculation of residual SYNTAX score (16). In those patients that underwent MIDCAB-first HCR or multi-vessel PCI, the residual SYNTAX score was based on the final angiogram, obtained after the last stents were placed. In those patients who had PCI-first HCR, the residual SYNTAX score was calculated assuming patency of the LIMA to LAD graft. For the CABG cohort, residual SYNTAX score was calculated based on the combination of the initial angiogram together with the operation report, assuming patency of the bypass grafts to the target vessels.