References:
[1]
Yadan,
J. C., Matching chemical properties to molecular biological activities
opens a new perspective on l-ergothioneine. FEBS LETT 2022,596 , 1299-1312.
[2]
Qian,
X., Hou, Q., Liu, J., Huang, Q., et al. , Inhibition of browning
and shelf life extension of button mushroom (Agaricus bisporus) by
ergothioneine treatment. SCI HORTIC-AMSTERDAM 2021, 288 ,
110385.
[3]
Pan,
H., Ye, Z., Zheng, Q., Yun, F., et al. , Ergothioneine exhibits
longevity-extension effect in Drosophila melanogaster via regulation of
cholinergic neurotransmission, tyrosine metabolism, and fatty acid
oxidation. FOOD FUNCT 2022.
[4]
Martin,
K. R., The bioactive agent ergothioneine, a key component of dietary
mushrooms, inhibits monocyte binding to endothelial cells characteristic
of early cardiovascular disease. J MED FOOD 2010, 13 ,
1340-1346.
[5]
Koh,
S. S., Ooi, S. C., Lui, N. M., Qiong, C., et al. , Effect of
Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.NEUROMOL MED 2021, 23 , 184-198.
[6]
Yoshida,
S., Shime, H., Funami, K., Takaki, H., et al. , The Anti-Oxidant
Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by
Direct Action on Macrophages. PLOS ONE 2017, 12 , e169360.
[7]
Yoshida,
S., Shime, H., Matsumoto, M., Kasahara, M., Seya, T., Anti-oxidative
Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to
Facilitate Adjuvant Vaccine Immunotherapy. FRONT IMMUNOL 2019,10 .
[8]
Bazela,
K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., et al. ,
l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A
Preliminary Study. COSMETICS-BASEL 2014, 1 , 51-60.
[9]
Hseu,
Y., Lo, H., Korivi, M., Tsai, Y., et al. , Dermato-protective
properties of ergothioneine through induction of Nrf2/ARE-mediated
antioxidant genes in UVA-irradiated Human keratinocytes. FREE
RADICAL BIO MED 2015, 86 , 102-117.
[10]
Cheah,
I. K., Feng, L., Tang, R. M. Y., Lim, K. H. C., Halliwell, B.,
Ergothioneine levels in an elderly population decrease with age and
incidence of cognitive decline; a risk factor for neurodegeneration?BIOCHEM BIOPH RES CO 2016, 478 , 162-167.
[11]
Nishida,
K., Takeuchi, K., Hosoda, A., Sugano, S., et al. , Ergothioneine
ameliorates oxaliplatin-induced peripheral neuropathy in rats.LIFE SCI 2018, 207 , 516-524.
[12]
Gründemann,
D., Harlfinger, S., Golz, S., Geerts, A., et al. , Discovery of
the Ergothioneine Transporter. Proceedings of the National Academy
of Sciences - PNAS 2005, 102 , 5256-5261.
[13]
Erdelmeier,
I., Daunay, S., Lebel, R., Farescour, L., Yadan, J., Cysteine as a
sustainable sulfur reagent for the protecting-group-free synthesis of
sulfur-containing amino acids: biomimetic synthesis of l-ergothioneine
in water. GREEN CHEM 2012, 14 , 2256.
[14]
Cremades,
O., Diaz-Herrero, M. M., Carbonero-Aguilar, P., Gutierrez-Gil, J.
F., et al. , White button mushroom ergothioneine aqueous extracts
obtained by the application of enzymes and membrane technology.FOOD BIOSCI 2015, 10 , 42-47.
[15]
YANG,
L., GONG, Q., GUO, J., LI, G., Microbes as a production host to produce
natural activecompounds from mushrooms: biosynthetic pathway
elucidationand metabolic engineering. CHIN J NAT MEDICINES 2021,19 , 580-590.
[16]
Lulu,
F., Hengchao, E., Yanmei, Z., Xiaobei, L., et al. , Research
Progress on Extraction, Separation and Detection of Ergothionine in
Edible Fungi. Acta Edulis Fungi 2021, 28 , 115-123.
[17]
Xiaoxue,
M., Xudong, C., Zhiwen, W., Yang, Y., et al. , Process Research of
Natural Antioxidant Ergothioneine. Chinese Journal of Synthetic
Chemistry 2022, 30 , 743-748.
[18]
Alamgir,
K. M., Masuda, S., Fujitani, Y., Fukuda, F., Tani, A., Production of
ergothioneine by Methylobacterium species. FRONT MICROBIOL 2015,6 .
[19]
Pfeiffer,
C., Bauer, T., Surek, B., Schömig, E., Gründemann, D., Cyanobacteria
produce high levels of ergothioneine. FOOD CHEM 2011, 129 ,
1766-1769.
[20]
Pluskal,
T., Ueno, M., Yanagida, M., Genetic and metabolomic dissection of the
ergothioneine and selenoneine biosynthetic pathway in the fission yeast,
S. pombe, and construction of an overproduction system. PLOS ONE2014, 9 , e97774.
[21]
Seebeck,
F. P., In Vitro Reconstitution of Mycobacterial Ergothioneine
Biosynthesis. J AM CHEM SOC 2010, 132 , 6632-6633.
[22]
Hu,
W., Song, H., Sae Her, A., Bak, D. W., et al. , Bioinformatic and
Biochemical Characterizations of C–S Bond Formation and Cleavage
Enzymes in the FungusNeurospora crassa Ergothioneine Biosynthetic
Pathway. ORG LETT 2014, 16 , 5382-5385.
[23]
Osawa,
R., Kamide, T., Satoh, Y., Kawano, Y., et al. , Heterologous and
High Production of Ergothioneine in Escherichia coli. J AGR FOOD
CHEM 2018, 66 , 1191-1196.
[24]
van
der Hoek, S. A., Darbani, B., Zugaj, K. E., Prabhala, B. K., et
al. , Engineering the Yeast Saccharomyces cerevisiae for the Production
of L-(+)-Ergothioneine. FRONT BIOENG BIOTECH 2019, 7 .
[25]
Takusagawa,
S., Satoh, Y., Ohtsu, I., Dairi, T., Ergothioneine production with
Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry2019, 83 , 181-184.
[26]
Ey,
J., Schömig, E., Taubert, D., Dietary Sources and Antioxidant Effects of
Ergothioneine. J AGR FOOD CHEM 2007, 55 , 6466-6474.
[27]
Yang,
X. Q., Lin, S. X., Lin, J. D., Wang, Y. Y., et al. , The
Biosynthetic Pathway of Ergothioneine in Culinary-Medicinal Winter
Mushroom, Flammulina velutipes (Agaric omycetes). INT J MED
MUSHROOMS 2020, 22 , 171-181.
[28]
Yu,
Y., Pan, H., Guo, L., Lin, J., et al. , Successful biosynthesis of
natural antioxidant ergothioneine in Saccharomyces cerevisiae required
only two genes from Grifola frondosa. MICROB CELL FACT 2020,19 .
[29]
Chen,
B., Xue, L., Wei, T., Ye, Z., et al. , Enhancement of
ergothioneine production by discovering and regulating its metabolic
pathway in Cordyceps militaris. MICROB CELL FACT 2022, 21 .
[30]
Tao,
P., Jinde, L., Yinghao, Y., Liqiong, G., Junfang, L., Expression in
Saccharomyces cerevisiae of Single Ergothioneine Synthase Genes from
Pleurotus. Food Science 2022, 43 , 214-219.
[31]
SHUI,
P., ZHENG, X., Guo, L., Lin, J., A simple and high-quality method for
total RNA extraction from edible fungi. Acta Edulis Fungi 2008,
32-36.
[32]
Zhang,
Y., Wang, J., Wang, Z., Zhang, Y., et al. , A gRNA-tRNA array for
CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces
cerevisiae. NAT COMMUN 2019, 10 .
[33]
Doyle,
S., Cuskelly, D. D., Conlon, N., Fitzpatrick, D. A., et al. , A
Single Aspergillus fumigatus Gene Enables Ergothioneine Biosynthesis and
Secretion by Saccharomyces cerevisiae. International Journal of
Molecular Sciences 2022, 23 , 10832.
[34]
Chen,
Z., He, Y., Wu, X., Wang, L., et al. , Toward more efficient
ergothioneine production using the fungal ergothioneine biosynthetic
pathway. MICROB CELL FACT 2022, 21 .
[35]
van
der Hoek, S. A., Rusnák, M., Wang, G., Stanchev, L. D., et al. ,
Engineering precursor supply for the high-level production of
ergothioneine in Saccharomyces cerevisiae. METAB ENG 2022,70 , 129-142.
[36]
Liang,
C., Huang, L., Ho, K., Lin, S., Mau, J., Submerged cultivation of
mycelium with high ergothioneine content from the culinary-medicinal
king oyster mushroom Pleurotus eryngii (higher Basidiomycetes) and its
composition. INT J MED MUSHROOMS 2013, 15 , 153.
[37]
TANG,
B., WU, L., WENG, M., LAI, P., LI, Y., Optimization of medium for
biosynthesis of ergothioneine by submerged fermentation of Pleurotus
eryngii 528. Fujian Journal of Agricultural Sciences 2021,36 , 728-734.
[38]
Sun,
G., Beijing University of Chemical Technology 2018.
[39]
Tanaka,
N., Kawano, Y., Satoh, Y., Dairi, T., Ohtsu, I., Gram-scale fermentative
production of ergothioneine driven by overproduction of cysteine in
Escherichia coli. SCI REP-UK 2019, 9 .
Table 1 Summary of EGT production
of engineered strains