2.3 The relationship between serum levels of IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 with sex and age in COVID-19 patients
According to the statistical analysis, as Table 1 shows, it was found that the serum levels of IL-10, MCP-1, TNF-α and IL-4 in male COVID-19 patients were markably higher than those in female patients (P=0.017, 0.004, 0.035, 0.012), while the differences of serum levels of IL-1β, IL-6 and IP-10 between male COVID-19 patients and female patients were not markably significant (P=0.057, 0.278,0.085).
Depending on the age distribution of COVID-19 patients we collected, they were divided into adolescents (aged from 8 to 35 years old), middle-aged people (aged from 36 to 59 years old) and elderly people (aged from 60 to 78 years old). According to the statistical analysis, as Table 2 shows, the serum levels of MCP-1 of the elderly were markably higher than those of adolescents and middle-aged patients (P=0.015, 0.000), and the levels of TNF-α and IL-4 in the serum of the elderly were markably higher than those of middle-aged patients (P=0.002, 0.035), but the difference in the levels of IL-10, IL-1β, IL-6 and IP-10 between COVID-19 patients at different ages were not statistically significant (P>0.05).