Discussion about clinical value of detection of IL-10, IL-1β,
IL-6, MCP-1, TNF-α, IP-10 and IL-4 for the diagnosis of COVID-19
Qingqing Lu1,Zhenhua Zhu2,Hui
Zhou2,Yan Hu2,Ge
Shen3,Pan Zhu3,Gang
Yang3,Xiaobing Xie2△
(1. Hunan University of Chinese medicine, Changsha Hunan Postal Code:
410208; 2. The First Hospital of Hunan University of Chinese Medicine,
Changsha Hunan Postal Code: 410007; 3. Loudi Center for Disease Control
and Prevention,Loudi Hunan Postal Code: 417000)
△ Correspondence author, E-mail:xxiaobing888@163.com
Abstract: Background and purpose : Studies have shown
that some cytokines of COVID-19 were elevated. This study aims to assess
whether IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 serve as
diagnostic biomarkers of COVID-19 and offer prognostic insight upon
initial presentation to help guide treatment, in addition, the
relationships between them and gender, age, antibody concentration and
course of disease were also discussed. Methods: The serum
levels of cytokines above in experience group (COVID-19 patients) and
control group (other diseases patients and healthy people) were detected
by ELISA. Results: Most of the serum level of cytokines above
in experience group were significantly higher than those in control
group, and AUCs of COVID-19 diagnosed by they were 0.735, 0.775, 0.595,
0.821, 0.848, 0.387 and 0.987. The serum levels of some cytokines in
male patients had noticeably higher than those in female patients, while
the serum levels of almost all cytokines of the elderly were higher than
that of the youth and middle-aged patients. The serum levels of IP-10 in
patients were positively correlated with IgM, while TNF-α were
negatively correlated with IgG. The levels of IL-1 β and IL-6 increased
sharply in the early stage of COVID-19, then decreased gradually; the
levels of IL-10, MCP-1, TNF-α and IL-4 increased sharply in the middle
stage, while the levels of IP-10 increased sharply in the late stage.Conclusion: The cytokines above can prove to be great
significance for clinical diagnostics of COVID-19, and the levels of
cytokines in patients have some relationships with gender, age and
course of disease.