Risk factors
In univariate logistic regression analysis, the occurrence of major and
contraindicated pDDIs was significantly associated with four
comorbidities (hypertension, diabetes, IHD, CRDs) and ICU admission as
an indicator of COVID-19 severity. Multivariate analysis showed the
independent predictors of occurrence of pDDIs are IHD (OR:5.3, [95%
CI:2.0-14.1], P = 0.001), CRDs (OR:3.6, [95% CI:1.1-12.1], P =
0.04), and ICU admission (OR:3.3, [95% CI:1.6-7.1], P = 0.002)
(table 4).