Authors’ contributions
Yong-Nu Zhang, Jian Xu, Yun-Feng Fu performed the experiments. Yong-Nu Zhang, Chun-Yu Huang analyzed the data. Ruo-Chun Lian recruited the patients. Yong-Nu Zhang wrote the manuscript. Chun-Yu Huang, Wen-Wei Tu reviewed the manuscript. Chun-Yu Huang, Wen-Wei Tu, Yong Zeng designed the study. All authors read and approved the final manuscript.
Funding This work was supported by the National Key Research & Developmental Program of China, China(2018YFC1003900/2018YFC1003904), Clinical Research Program of Chinese Medical Association, China (17020340703), Shenzhen Healthcare Research Project, China (SZXJ2018004), and the Sanming Project of Medicine in Shenzhen, China (SZSM201502035).