SECTIONS | CONTRIBUTORS |
MAIN TEXT | |
Abstract | AP, MCT, SK, EJJ, PW |
1. Introduction | AP, MCT, UR, LC, GN, SK |
2. Allergy: Current and emerging biomarkers, and therapeutic approaches | AP, MME, UR, UJ, DEF, MPa ,EI, SK, LV, EJJ |
2.1. Immune dysregulation | DEF, UJ, MPa |
2.2. Current and emerging biomarkers in the diagnosis and treatment | UJ, MME, UR, EI, LV, DEF, Mpa, EJJ |
2.2.1. Clinically-used biomarkers | |
2.2.2. Emerging cellular markers | |
2.2.3. Emerging type-2 cytokines and proteins | |
2.2.4. Emerging genetic and molecular omics markers | MME, UR, UJ |
2.3.Therapeutic approaches | ChB, UJ, MPa, LV |
3. Glioma: Updated classification, immune biomarkers, and therapeutic approaches | PW |
3.1. Diagnosis and classification | PW, AP |
3.2. Immune response and biomarkers | MPr, SN |
3.3. Immune-therapeutic approaches | MW |
4. Epidemiological, clinical and pre-clinical studies of allergy and glioma | MCT, AMC, AP, SK |
4.1. Studies of allergy and glioma risk | MCT, AMC, AP, SK |
4.2. Studies of allergy and glioma prognosis | AMC, AP, SK, MCT |
4.3 Pre-clinical studies of allergy and glioma | AP |
5. Future research in AllergoOncology | All authors |
6. Conclusion | All authors |
REFERENCES | |
FIGURES | |
Figure 1: Proposed hypotheses of associations between allergic disorders and cancer development and progression within the concept of immunosurveillance and immunoediting. | AP, NRU |
Figure 2: Overview of allergic inflammation: cellular and molecular mechanisms | AP |
Figure 3: WHO classification of gliomas over time | PW, RT |
Figure 4: The border-associated immune compartments of the brain | AP, FLH |
Figure 5: Allergic inflammation modulation of central nervous system (CNS) homeostasis. | AP |
Figure 6: Future research in AllergoOncology | AP |
BOXES | |
Box 1: Allergic inflammation and brain physiology | AP, FLH |
Box 2: Research questions for new studies in allergy and glioma risk, prognosis, and treatment | AP, MCT, EJJ, SNK |
TABLES | |
Table 1: Selected biomarkers and individual demographics to study links between allergic diseases and gliomas | All |
Table 2: Biological drugs targeting molecules relevant for atopic / allergic disease pathomechanisms | UJ, ChB |
SUPPLEMENTARY MATERIALS | |
METHODS | AP |
SUPPLEMENTARY TABLE 1: WHO classification of gliomas in 2007 (4th edition), 2016 (revised 4th edition) and 2021 (5th edition) | PW |