Figure 4. (A) A venn diagram showing overlaps between BCG
genetic mimics and key hubs with SARS-CoV-2 and Corona viruses
interactomes. (B) Top “pathway map” with the highest level of
enrichment by genes in BCG-CGS. This map is generated using MetaCore
from Clarivate Analytics. Red thermometers indicate genes overexpressed
in response to BCG treatment, and the hight of the red bars is
representative of the differential gene expression level (i.e.,
log2 values of the fold change). The numbers under the
thermometers 1- 5 refer to the experiment number: 1) gene expression on
day 1 in response to BCG vaccination to a BCG-naïve population on day 1;
2) gene expression on day 1 in response to BCG re-vaccination to a
previously vaccinated population; 3) gene expression on day 1 in
response to BCG vaccination to a BCG-naïve population on day 14; 4) gene
expression on day 14 in response to BCG re-vaccination to a previously
vaccinated population, and 5) positive connections from the connectivity
map, and the red bar in the thermometer number 5 represents presence of
the gene only.