T-ALL with CDKN2A gene deletion was characterized by higher
male/female ratio,more older children and higher WBC counts
We compared the difference of clinical variables and cytogenetic risk
group between T-ALL and B-ALL (Table 2).The clinical features of the
T-ALL subgroup(n=24) were clearly distinct from the B-ALL
subgroup(n=87).The CDKN2A gene deletions were more prevalent in male
than female in T-ALL
subgroup(P =0.002).45.8%(11/24)patients
with CDKN2A deletion were older than ten years old in the T-ALL
subgroup(P =0.006).CDKN2A deletion was more prevalent in T-ALL
childrenwith WBC counts of greater than
50x109/Lcompared to B-ALL
subgroup(P =0.000).There was no significant difference among two
immunophenotypic subgroupsfor age,hepatosplenomegaly,CNS2,cytogenetic
risk groups, andkaryotype including del(9)(p21).