T-ALL with CDKN2A gene deletion was characterized by higher male/female ratio,more older children and higher WBC counts
We compared the difference of clinical variables and cytogenetic risk group between T-ALL and B-ALL (Table 2).The clinical features of the T-ALL subgroup(n=24) were clearly distinct from the B-ALL subgroup(n=87).The CDKN2A gene deletions were more prevalent in male than female in T-ALL subgroup(P =0.002).45.8%(11/24)patients with CDKN2A deletion were older than ten years old in the T-ALL subgroup(P =0.006).CDKN2A deletion was more prevalent in T-ALL childrenwith WBC counts of greater than 50x109/Lcompared to B-ALL subgroup(P =0.000).There was no significant difference among two immunophenotypic subgroupsfor age,hepatosplenomegaly,CNS2,cytogenetic risk groups, andkaryotype including del(9)(p21).