Association of cord blood soluble FasL levels with atopic outcomes
at 7 years old
The mean values and standard deviations for the cord blood soluble FasL
levels in 7-year-old children with or without specific allergic outcomes
are shown in Table 1. We observed that the cord blood soluble FasL
levels were significantly higher in 7-year-old children with atopy
(p = .003), D. pteronyssinus sensitization (p =
.003), and allergic rhinitis (p = .016). The cord blood soluble
FasL levels of these 7-year-old children with asthma and atopic
dermatitis were not elevated at birth.
The FeNO levels at 7 years were also positively correlated with the cord
blood soluble FasL levels (r2 = .077, p = .006,
Figure 2A). Similarly, Dermatophagoides pteronyssinus -specific
immunoglobulin E levels at 7 years were positively correlated with cord
blood soluble FasL levels (r2 = .057, p = .02,
Figure 2B). The 7-year-old children with expiratory airway obstruction
(FEV1/FVC < 90%) had significantly higher cord soluble FasL
levels at birth (p = .022, Table 1).