Pathway Total Expected Expected Hits P.Value FDR
Alzheimer’s disease 171 71 104 104 2.10E-07 5.03E-05
Oxidative phosphorylation 133 55.2 84 84 3.16E-07 5.03E-05
Parkinson’s disease 142 58.9 88 88 5.66E-07 6.00E-05
Chemokine signaling pathway 190 78.9 105 105 7.50E-05 0.00596
Malaria 49 20.3 33 33 0.000221 0.0141
Dopaminergic synapse 131 54.4 74 74 0.000346 0.0173
Phagosome 152 63.1 84 84 0.000381 0.0173
Spliceosome 134 55.6 75 75 0.000463 0.0184
Non-alcoholic fatty liver disease (NAFLD) 149 61.8 82 82 0.00053 0.0187
Chagas disease (American trypanosomiasis) 103 42.7 59 59 0.000832 0.0265
Notch signaling pathway 48 19.9 31 31 0.00102 0.0295
Protein processing in endoplasmic reticulum 165 68.5 88 88 0.00129 0.0316
Salmonella infection 86 35.7 50 50 0.00129 0.0316
Platelet activation 124 51.5 68 68 0.00173 0.0387
Pathogenic Escherichia coli infection 55 22.8 34 34 0.00182 0.0387
Huntington’s disease 193 80.1 100 100 0.00218 0.0434
Pathways in cancer 530 220 251 251 0.00274 0.051
Osteoclast differentiation 128 53.1 69 69 0.00289 0.051
Fc gamma R-mediated phagocytosis 91 37.8 51 51 0.00343 0.0575
Complement and coagulation cascades 79 32.8 45 45 0.00383 0.0609
Oxytocin signaling pathway 153 63.5 80 80 0.00423 0.064
Th1 and Th2 cell differentiation 92 38.2 51 51 0.00464 0.0671
Epithelial cell signaling in Helicobacter pylori infection 68 28.2 39 39 0.00586 0.0773
Hematopoietic cell lineage 97 40.3 53 53 0.00587 0.0773
Leukocyte transendothelial migration 112 46.5 60 60 0.00627 0.0773
Tight junction 170 70.6 87 87 0.00632 0.0773
Apoptosis 136 56.4 71 71 0.00711 0.0838
FoxOsignaling pathway 132 54.8 69 69 0.0076 0.0863
Mitophagy - animal 65 27 37 37 0.00845 0.0882
Shigellosis 65 27 37 37 0.00845 0.0882
Prion diseases 35 14.5 22 22 0.00867 0.0882
Primary immunodeficiency 37 15.4 23 23 0.00888 0.0882
Epstein-Barr virus infection 201 83.4 100 100 0.0102 0.0932
Pertussis 76 31.5 42 42 0.0104 0.0932
Focal adhesion 199 82.6 99 99 0.0105 0.0932
Calcium signaling pathway 188 78 94 94 0.0106 0.0932
Amphetamine addiction 68 28.2 38 38 0.0114 0.098
Vibrio cholerae infection 50 20.8 29 29 0.0134 0.112
Regulation of actin cytoskeleton 214 88.8 105 105 0.0141 0.113
Retrograde endocannabinoid signaling 148 61.4 75 75 0.0143 0.113
HTLV-I infection 219 90.9 107 107 0.0153 0.119
Kaposi’s sarcoma-associated herpesvirus infection 186 77.2 92 92 0.016 0.119
Carbon metabolism 116 48.1 60 60 0.016 0.119
Endocytosis 244 101 118 118 0.0164 0.119
Phosphatidylinositol signaling system 99 41.1 52 52 0.0168 0.119
Legionellosis 55 22.8 31 31 0.0182 0.126
Chronic myeloid leukemia 76 31.5 41 41 0.0187 0.126
Proteasome 45 18.7 26 26 0.0199 0.132
Hippo signaling pathway -multiple species 29 12 18 18 0.0203 0.132
Proteoglycans in cancer 201 83.4 98 98 0.021 0.134
Ribosome 153 63.5 76 76 0.0239 0.149
Cellular senescence 160 66.4 79 79 0.0255 0.156
B cell receptor signaling pathway 71 29.5 38 38 0.0267 0.16
2-Oxocarboxylic acid metabolism 18 7.47 12 12 0.0276 0.161
Circadian entrainment 97 40.3 50 50 0.0283 0.161
Long-term potentiation 67 27.8 36 36 0.0285 0.161
ECM-receptor interaction 82 34 43 43 0.0289 0.161
Basal cell carcinoma 63 26.1 34 34 0.0303 0.166
Autophagy - animal 128 53.1 64 64 0.0309 0.166
Apelinsignaling pathway 137 56.9 68 68 0.0319 0.169
Cell adhesion molecules (CAMs) 146 60.6 72 72 0.0328 0.171
Adherens junction 72 29.9 38 38 0.0344 0.173
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 72 29.9 38 38 0.0344 0.173
Natural killer cell mediated cytotoxicity 131 54.4 65 65 0.0356 0.177
Non-small cell lung cancer 66 27.4 35 35 0.0381 0.186
Glucagon signaling pathway 103 42.7 52 52 0.0398 0.188
Oocyte meiosis 125 51.9 62 62 0.0398 0.188
Cytokine-cytokine receptor interaction 294 122 137 137 0.0407 0.188
Hippo signaling pathway 154 63.9 75 75 0.0408 0.188
Endometrial cancer 58 24.1 31 31 0.0436 0.198
Fructose and mannose metabolism 33 13.7 19 19 0.0455 0.204
cGMP-PKG signaling pathway 166 68.9 80 80 0.0462 0.204
IL-17 signaling pathway 93 38.6 47 47 0.0479 0.209
Rheumatoid arthritis 91 37.8 46 46 0.0497 0.214