Datasets used in this study
Datasets used in the meta-analysis: SARS-Cov-2 (Calu-3)- Calu-3 cells
either mock-infected (control) or infected with SARS-CoV-2 (strain
USA-WA1/2020), (MOI 2), were collected after 24 hours of treatment
(control-3, infected-3) and subjected to RNA-seq as described in
GSE147507.RSV (A549) - A549 cells either mock-infected (control) or
infected with RSV (strain A2), (MOI 15), were collected after 24 hours
of treatment (control-2, infected-2) and subjected to RNA-seq as
described in GSE147507.H1N1 (A549) - A549 cells either mock-infected
(control) or infected with H1N1 (strain A/Puerto Rico/8/1934), (MOI 5),
were collected after 9 hours of treatment (control-2, infected-2) and
subjected to RNA-seq as described in GSE147507.SARS (Calu-3)- Calu-3
subclone 2B4 cells either mock-infected (control) or infected with
SARS-CoV, (MOI 0.1), were collected after 24 hours of treatment
(control-3, infected-3) and subjected to microarray as described in
GSE17400.H3N2 (Calu-3) – Calu-3 cells either uninfected (control) or
infected with H3N2, were collected after 24 hours of treatment
(control-2, infected-3) and subjected to microarray as described in
GSE19580.SARS-Cov-2 (A549)-A549 cells either mock-infected (control) or
infected with SARS-CoV-2 (strain USA-WA1/2020), (MOI 0.2), were
collected after 24 hours of treatment (control-3, infected-3) and
subjected to RNA-seq as described in GSE147507.
The data sets used for the integrated analysis: SARS-Cov-2 (Calu-3);
SARS-Cov-2 (A549), as described in previous section; Covid patient BALF-
RNA-seq was performed on peripheral blood mononuclear cells (PBMCs) from
3 Covid-2019 patients and bronchoalveolar lavage fluid (BALF) from 2 of
the Covid-2019 patients as described in GSA id PRJCA002326.Covid-19 lung
(Autopsy)- RNA-seq was performed on a total of 15 lung sections from 5
Covid-2019 patients and 5 lung sections used as negative control as
described in GSE150316. Diet induced obesity and diabetes (DIOD) rodent
lung 1- RNA-seq was performed on lung tissue obtained from 3 C57BL/6J
mice fed with 60% High Fat Diet (obese mice) as well as 3 mice fed with
10% Low Fat Diet (lean control) as described in GSE123938. Diet induced
obesity and diabetes (DIOD) rodent lung 2- RNA-seq was performed on lung
tissue obtained from 4 C57BL/6 mice fed with 40% High Fat Diet (obese
mice) as well as 4 mice fed with 12% Low Fat Diet (lean control) as
described in GSE3963412.