Study SNP Gene Effect
Metformin Metformin Metformin Metformin
Trilla-Fuertes L 2018113 rs2282143 SLC22A1 Affecting the efficiency of metformin entering cells
Lopez-Bermejo A 2010115 rs8111699 LKB1 Influencing both insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess
Jablonski KA 2010116 rs11212617 ATM Affecting glycemic response to metformin
Zhou 2011117 rs9803799 PRKAA2 Affecting generation of AMPK
Rapamycin Rapamycin Rapamycin Rapamycin
Trilla-Fuertes L 2018113 rs2740574 CYP3A4 Affecting the metabolism of rapamycin in the liver
Lu 201683 rs6723868 DHX57 Correlated with chronological age
Lu 201683
rs30986 rs27709 rs26840 rs27648 MLST8 MLST8 MLST8 MLST8
Correlated with smaller epigenetic age than chronological age in the cerebellum, a part of mTOR complexes