loading page

Mechanisms under Metformin and Rapamycin as Anti-aging Drugs
  • +2
  • Qian Feng,
  • Bangwei Chen,
  • Chuyao Wang,
  • Chao Nie,
  • TAO LI
Bangwei Chen
Author Profile
Chuyao Wang
Author Profile
Chao Nie
BGI-Shenzhen
Author Profile

Peer review status:UNDER REVIEW

02 Jul 2020Submitted to Advanced Genetics
02 Jul 2020Assigned to Editor
02 Jul 2020Submission Checks Completed
13 Jul 2020Review(s) Completed, Editorial Evaluation Pending

Abstract

As percentages of elderly people rise in many societies, age-related diseases have become more prevalent. Research interests have been shifting to delaying age-related disease by delaying or reversing aging itself. We use metformin and rapamycin, two drugs at the center of anti-aging drug research, as an entry point to talk about important molecular and genetic anti-aging mechanisms that have been extensively studied with them, such as mTOR, AMPK, and epigenetic modifications. We also present a number of observational studies, animal studies, and clinical trials to reflect the potential and actual effects of the mechanisms. At the end, we list remaining concerns that not only apply to researches around metformin and rapamycin but also future researches to explore other anti-aging pathways and therapeutics.