Data sources and search strategy
A total of 24 articles were found involving MK-677, GH secretagogue, sarcopenia, insulin-like growth factor-1, safety, and efficacy. Initially, it was held the existing exclusion title and duplications following the interest described in this work. After this process, 14 articles were included and discussed in this study (Figure 1). PUBMED, EMBASE, OVID AND COCHRANE LIBRARY databases were searched. Initially, the descriptors were determined by searching the DeCS tool and later verified and validated by the MeSH Terms System (US National Library of Medicine).The present study was elaborated according to the rules of systematic review- PRISMA (Transparent reporting of systematic reviews and meta-analyses- http://www.prisma-statement.org/).