ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS ALL EXHALED BREATH OBSERVATIONS
Experimental Experimental Natural Natural P value P value
(39 subjects; 84 GII obs.) (39 subjects; 84 GII obs.) (83 subjects; 146 GII obs.) (83 subjects; 146 GII obs.)
Coarse Fine Coarse Fine Coarse Fine
No. positive subjects (%) 6 (15) 11 (28) 45 (54) 71 (86) 6E-5 7E-10
No. positive samples (%) 6 (7) 14 (17) 66 (45) 111 (76) 2E-10 7E-19
GM (GSD)
2.7E+3 (3.3)
5.1E+3 (4.7)
1.8E+4 (13.9)
3.9E+4 (15.1)
0.002 (t = -3.9, df = 12.9) 0.005 (t = -3.3, df = 16.1)
RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile
25th ND ND ND 1.3E+3
Median ND ND ND 7.9E+3 E-9 3E-18
75th ND ND 6.6E+3 7.6E+4
90th ND 2.0E+3 7.4E+4 1.1E+6
95th 1.3E+3 6.4E+3 8.5E+5 6.5E+6
Maximum 2.8E+4 8.0E+4 4.3E+8 4.4E+7
MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS MAXIMUM SHEDDING EXHALED BREATH OBSERVATIONS
Experimental Experimental Natural Natural P value P value
(11 subjects; 11 GII obs.) (11 subjects; 11 GII obs.) (71 subjects; 71 GII obs.) (71 subjects; 71 GII obs.)
Coarse Fine Coarse Fine Coarse Fine
GM (GSD)
2.7E+3 (3.3)
5.0E+3 (5.8)
2.1E+4 (16.5)
5.1E+4 (17.0)
0.0002 (t = -4.2, df = 35.9) 0.003 (t = -3.5, df = 14.7)
RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile RNA copies by percentile
25th ND 1.5E+3 ND 5.8E+3
Median ND 2.0E+3 1.7E+3 2.2E+4 0.02 0.003
75th ND 3.5E+4 1.0E+4 3.9E+5
90th 1.4E+3 6.7E+4 4.2E+5 6.3E+6
95th 2.2E+3 7.4E+4 9.8E+5 1.4E+7
Maximum 2.8E+4 8.0E+4 4.3E+8 4.4E+7
Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value. Samples collected Days 1-4 post inoculation in the experimentally infected and Days 1-3 post symptom onset in the naturally infected. Shedding per half hour sample. GM, geometric mean. GSD, geometric standard deviation; ND, not detected. Only samples with detectable RNA (at least one positive replicate) contributed to GM and GSD (fine aerosol: N=14 experimental, N=111 natural; coarse aerosol: N=6 experimental, N=66 natural). When restricted to samples with detectable RNA, Wilcoxon rank sum tests gave p=0.03 (coarse) and p=0.003 (fine). df=degrees of freedom; t=t-test value.