Predictor
Experimental OR (95% CI) Natural OR (95% CI) Combined Groups OR (95% CI)
Age 1.05 (0.92-1.19) 0.98 (0.93-1.04) 0.9 (0.85-0.95)
Sex - 2.22 (0.99-4.97) 1.19 (0.62-2.29)
Study day Study day Study day Study day
Day 1
-
1.00 (REF)
-
Day 2
1.00 (REF)
0.25 (0.06-1.03)
-
Day 3
50.89 (0.07-30,636)
0.17 (0.04-0.73)
-
Day 4
0 (0-7.51)
-
-
Ever fever >37.9oC 4.51 (0.48-42.28) 0.72 (0.33-1.55) 2.62 (1.24-5.54)
Body Temperature (oC) 4.77 (0.94-24.17) 1.88 (0.87-4.06) 6.11 (3.11-12)
Upper respiratory score 2.24 (1.07-4.69) 1.07 (0.93-1.22) 1.42 (1.26-1.61)
Lower respiratory score 6.49 (1.14-37.09) 1.35 (1.04-1.76) 2.12 (1.67-2.69)
Systemic symptom score 1.73 (0.94-3.16) 1.15 (0.97-1.36) 1.56 (1.34-1.82)
Total symptom score 1.64 (1.09-2.47) 1.07 (0.99-1.15) 1.21 (1.13-1.29)
Cough symptom score§ Cough symptom score§ Cough symptom score§ Cough symptom score§
No symptom
1.00 (REF)
1.00 (REF)
1.00 (REF)
Mild
7.49 (1.28-43.91)
8.5 (0.81-88.85)
10.54 (4.1-27.11)
Moderate
-
12.92 (1.32-126.08)
23.69 (9.31-60.28)
Severe
-
20.4 (2.06-202.21)
37.4 (14.15-98.84)
Cough count 1.29 (1.02-1.62) 1.92 (1-3.65) 5.43 (2.67-8.62)
Nasopharyngeal swab Ct 0.74 (0.6-0.92) 0.98 (0.91-1.05) 0.89 (0.84-0.94)
N=84 experimental, N=146 natural, N=230 combined observations (all exhaled breath observations from 39 experimental and 83 natural cases). Effect of a single unit increase in age, body temperature, symptoms scores, an nasopharyngeal swab Ct; effect of interquartile range (IQR) increase in cough count, ever febrile>37.9oC versus afebrile, male versus female. Bold: significant at p<0.05. Only males shed into aerosols in the experimental group. Day postnasal inoculation for experimental (range 1-4); day post symptom onset for natural (range 1-3). No fine aerosol shedding was observed on day 1 post inoculation. Differences in meaning for study day precluded combined group estimates. §Moderate or severe cough was never observed in the experimental group. N=84 experimental, N=146 natural, N=230 combined observations (all exhaled breath observations from 39 experimental and 83 natural cases). Effect of a single unit increase in age, body temperature, symptoms scores, an nasopharyngeal swab Ct; effect of interquartile range (IQR) increase in cough count, ever febrile>37.9oC versus afebrile, male versus female. Bold: significant at p<0.05. Only males shed into aerosols in the experimental group. Day postnasal inoculation for experimental (range 1-4); day post symptom onset for natural (range 1-3). No fine aerosol shedding was observed on day 1 post inoculation. Differences in meaning for study day precluded combined group estimates. §Moderate or severe cough was never observed in the experimental group. N=84 experimental, N=146 natural, N=230 combined observations (all exhaled breath observations from 39 experimental and 83 natural cases). Effect of a single unit increase in age, body temperature, symptoms scores, an nasopharyngeal swab Ct; effect of interquartile range (IQR) increase in cough count, ever febrile>37.9oC versus afebrile, male versus female. Bold: significant at p<0.05. Only males shed into aerosols in the experimental group. Day postnasal inoculation for experimental (range 1-4); day post symptom onset for natural (range 1-3). No fine aerosol shedding was observed on day 1 post inoculation. Differences in meaning for study day precluded combined group estimates. §Moderate or severe cough was never observed in the experimental group. N=84 experimental, N=146 natural, N=230 combined observations (all exhaled breath observations from 39 experimental and 83 natural cases). Effect of a single unit increase in age, body temperature, symptoms scores, an nasopharyngeal swab Ct; effect of interquartile range (IQR) increase in cough count, ever febrile>37.9oC versus afebrile, male versus female. Bold: significant at p<0.05. Only males shed into aerosols in the experimental group. Day postnasal inoculation for experimental (range 1-4); day post symptom onset for natural (range 1-3). No fine aerosol shedding was observed on day 1 post inoculation. Differences in meaning for study day precluded combined group estimates. §Moderate or severe cough was never observed in the experimental group.