Long term mortality
Over a mean period of 2.3 + 1.5 years, 71/1071 (6.6 %) patients of the entire cohort died. Mortality was significantly higher among patients with moderate to severe TR (9/32, 28%) compared to patients with no/mild TR (62/1039, 6%; p<0.001, Figure 2).
Multivariate Cox hazard analysis for moderate-severe TR adjusted for significant clinical and echocardiographic parameters is shown in Table 4. The mortality HRs of moderate to severe TR (2.44; 95% CI, 1.06-5.6; P = 0.03) remained significant even after adjustment for gender, family history, hypertension (HTN), estimated glomerular filtration rate (EGFR) <60, EF, E/e′ ratio and SPAP.