Antioxidant activity of Lactobacillus
The gastrointestinal (GI) tract is challenged with oxidative stress
induced by a wide array of factors, such as exogenous pathogenic
microorganisms and dietary aspects. Redox signaling plays a critical
role in the physiology and pathophysiology of the GI tract93. The redox mechanisms of Lactobacillus spp.
are involved in the downregulation of ROS-forming enzymes,94,95 and redox stress resistance proteins or genes
differ largely between LAB species. In addition, Nrf-2 and NF-κB are two
common transcription factors, through which Lactobacillus spp.
also modulates oxidative stress. 96