Survival curves of in-hospital death
The low CD4+T cells count group (<404
cells/ul) had a higher in-hospital death rate than the high
CD4+T cells count group (≥404 cells/ul) during the
follow-up period (log rank<0.001, Figure S2).
Results of Cox
proportional hazards analyses of in-hospital death
Cox proportional hazard regression analysis was performed to test the
associations between the low CD4+T cells count group
and in-hospital death for severe COVID-19 patients. Results of
univariate analyses indicated that patients with CD4+T<440
cells/ul exhibited a 15.72-fold increase in in-hospital death compared
to patients with CD4+T≥440 cells/ul (hazard ratio (HR)
:15.72; 95% confidence intervals (CI):3.67-67.35). Meanwhile, age,
history of hypertension, white blood cell count, platelet count,
lymphocyte count, lymphocyte count low group, creatinine, estimated
glomerular filtration rate, D-dimer, sodium ions,
CD3+T cells low group, CD8+T low
group, presenting ground-glass opacity or local patchy shadowing on CT
imaging, required mechanical ventilation or glucocorticoids or
intravenous immunoglobulin treatment or antifungal treatment were
correlated with the risk of in-hospital death in patients with severe
COVID-19 (table 2).
Multivariate survival analysis was
performed to identify the independent factors correlated with prognosis.
In each model, CD4+T (the low group vs. the high
group) was significance which demonstrated that presenting with
CD4+T cells count below 404 cells/ul was an
independent risk factor for in-hospital death. In addition, variables
like white blood cell count, age and platelet count also showed
significance for independently predicting in-hospital death in this
study (Table S1).