Study design and setting
We constructed a prospective cohort of consecutive pregnant women with confirmed SARS-CoV-2 infection (positive RT-PCR on nasopharyngeal swab) who delivered in BCNatal (Hospital Clínic and Hospital Sant Joan de Déu), Barcelona, Spain between March 13th and April 25th, 2020.
Clinical management and follow-up of these patients was made from admission until hospital discharge according an established protocol(14). Moderate or severe cases started treatment for COVID with lopinavir/ritonavir, hydroxychloroquine and azithromycin. Maternal monitoring during admission or labor included hourly monitoring of blood pressure, heart rate, temperature, respiratory rate and oxygen saturation. Labor was managed by attending professionals adhering to personal protection equipment protocols, in a dedicated delivery room under continuous fetal cardiotocographic monitoring. The mode of delivery in women with COVID-19 with no criteria of severe disease was guided by standard obstetric indications. After hospital discharge, telephone follow-up was performed to detect postpartum complications.