Data Extraction and Assessment of Risk of Bias
Titles, abstracts, and citations were independently analyzed by the authors (JC-R, CR-M). From the full text, all studies were independently assessed for inclusion. The authors were independently involved in all stages of study selection, data extraction, and risk of bias assessment. The latter was assessed according to recommendations outlined in the Cochrane Handbook15 for the following items: 1) adequacy of sequence generation; 2) allocation concealment; 3) blinding of participants and investigators; 4) blinding of outcome assessment; 5) incomplete outcome data; 6) selective outcome reporting, and other bias. Disagreements were discussed and resolved by consensus.