Managing DDIs
All HCQ prescriptions were analyzed by clinical pharmacists. Then
multidisciplinary meetings were carried out with physicians in order to
evaluate and manage DDIs.
Among the 60 contraindicated and not recommended drugs with HCQ, 32
(53%) were stopped or modified: 25 before starting HCQ treatment and 7
during HCQ treatment. All the contraindicated drugs (n=13) were
discontinued: 9 before initiation of HCQ, 3 on the first day of
treatment and 1 two days after HCQ initiation.
The other 28 not recommended drugs (47%) were not discontinued during
HCQ treatment. Main drugs were PPI (10/28), loop diuretic (5/28) and
inhaled-bronchodilator (4/28).