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Disability-adjusted Life Years for Acute Bronchiolitis
  • jefferson buendia
jefferson buendia
University of Antioquia
Author Profile

Peer review status:UNDER REVIEW

30 Jun 2020Submitted to Pediatric Pulmonology
30 Jun 2020Assigned to Editor
30 Jun 2020Submission Checks Completed
04 Jul 2020Reviewer(s) Assigned
20 Jul 2020Review(s) Completed, Editorial Evaluation Pending

Abstract

BACKGROUND: The burden of disease generated by acute bronchiolitis (AB) in infants is unknown in developing countries. Evidence on the disease burden is important for decision-making processes within the health sector. The objective of the present study is to determine the Disability-Adjusted Life Years in a middle-income country METHODS: DALYs were calculated, using the methodology of Global Burden of Disease Study, for the following health outcomes of AB: AB uncomplicated, AB with complications, AB with severe complications, with long term complications. To estimate the DALY of each outcome, we performed a systematic review of evidence and complemented with information from the national epidemiological surveillance system. Sensibility analysis was made using a bootstrapped method with 10000 iterations in package DALY calculator of R program. RESULTS: In 2019, we estimated that 482 993 years of life (IC 95% 366 565- 690 294) were lost due to AB in infants. The rate of DALYs estimated for AB with mild complications were 19 DALYs / 1000 person-year, 6 DALYs / 1000 person-year for AB with severe complications, 6 DALYs / 1000 person-year for AB uncomplicated CONCLUSION: The burden of AB is a serious problem in Colombia, with a considerable social impact in terms of disability and mortality. It is necessary novel pharmacological strategies to minimize the impact of this serious problem in Colombia.